While discussing her career highlights with Entertainment Weekly, Jennifer Esposito opened up about how she once told “Samantha Who?” co-star Melissa McCarthy to change up her shoes. “She was pregnant when we filmed the pilot … They had her in this outfit and she had these little socks, these little boots that were literally cutting off her circulation … [I told her to] get them off,” “The Boys” actor said.
“Samantha Who?” consistently paired up Esposito and McCarthy’s characters together as Samantha’s best friends, so it makes sense that they became friends off-screen. The ABC sitcom frequently played with how Esposito and McCarthy’s characters were radically different, often giving Samantha differing advice. In a 2008 interview with Wood TV ahead of the show’s release, Esposito detailed the chemistry she and McCarthy share on set. “Usually if I’m in a scene with Melissa, I will hear her giggle inappropriately,” the actress revealed. “Or if we’re in a scene and the camera’s not on me, and she’s doing it, I’m hysterical. So, we kind of think we’re both funny. We don’t know if anyone else does.”
Years later, Esposito revealed how McCarthy was concerned for her health when a tooth fell out while they were filming the series, further solidifying their friendship. “Melissa McCarthy says to me, ‘Something is wrong, you are ill,'” Esposito said on “Oprah: Where Are They Now?” McCarthy’s concern was warranted, as Esposito revealed that she was later diagnosed with Celiac disease.